CLEC9A (which has also been termed DNGR1) is the most recently characterized receptor from the Dectin-1 cluster and is expressed in many tissues.In peripheral blood, human CLEC9A is found primarily on the surface of BDCA3+ DCs, although this receptor was also detected on small subsets of monocytes and B-cells. CLEC9A may function as an activation receptor, and was capable of internalizing bound antigens via endocytosis and directing them to the endosomal/lysosomal pathway, resulting in enhanced humoral, CD4+ and CD8+ T-cell responses, even in the absence of adjuvant.