Type

Mouse Anti Human Monoclonal

Introduction

IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Clone

NYRhIL4

Immunogen

rHuman IL-4

Ig Subclass

Mouse IgG1

Purification Method

Protein A column.

Usage

FOR LABORATORY RESEARCH USE ONLY.

Applications

Direct ELISA, Western Blot, Immuneprecipitation, Immunohistochemistry, Intracellular staining. Immunohistochemistry, Intracellular staining.