Type

Rat Anti Mouse Monoclonal

Introduction

IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

Clone

NYRmIL-10

Immunogen

rMurine IL-10

Ig Subclass

Rat IgM

Purification Method

Protein A column.

Usage

FOR LABORATORY RESEARCH USE ONLY.

Applications

Direct ELISA, Western Blot, Immuneprecipitation Immunohistochemistry, Intracellular staining.